Neurodegeneration and Genetics

 Neurodegeneration marked by gradual loss of neuronal structure and its functions, including death of neurons, The most common neurodegenerative diseases are Alzheimer’s disease and Parkinson’s disease. Degenerative nerve diseases have an effect on many of your body's activities, which includes balance, movement, talking, respiration, and coronary heart function, many of these diseases are genetic, sometimes the reason is a scientific condition which include alcoholism, a tumor, or a stroke, other reasons can also include pollution, chemicals, and viruses, sometimes the purpose is not known. Degenerative nerve diseases include are Alzheimer's disease, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Lewy body disease, Parkinson's disease and Spinal muscular atrophy

Many neurodegenerative diseases are due to genetic mutations for example the gene CAG encodes for the amino acid glutamine which get mutated to produce repetition of the CAG nucleotide triplet results polyglutamine (polyQ) tract known as polyglutamine diseases. The major examples of neurodegenerative diseases are spinocerebellar ataxias and Huntington's disease.

  • Epidemiology of Neurodegenerative disease
  • Molecular bases of neurodegenerative disease
  • Disease-relevant variants in Sporadic diseases
  • Gene expression
  • Genetic epidemiology
  • Genetic Mutations
  • Neurogenetics
  • Neurogenesis
  • Glutamine and Polyglutamine
  • Protein misfolding
  • Proteopathies
  • Beta amyloid
  • Senile plaques 
  • Prion and transmissible spongiform encephalopathies
  •  Epigenetic therapy

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